COLORECTAL CARCINOMA AFFECTED PATIENTS ARE SIGNIFICANTLY POOR RESPONDERS AGAINST THE ONCOGENIC JC POLYOMAVIRUS

Colorectal Carcinoma Affected Patients Are Significantly Poor Responders Against the Oncogenic JC Polyomavirus

BackgroundMany investigations reported the association between human tumors and JCPyV, a polyomavirus with oncogenic potential.The association has been supported by studies that found JCPyV footprints in CRC and gliomas of different types.Indeed, JCPyV footprints including its nucleic acids and Tag oncoprotein have been revealed in CRC tissues.Meth

read more




Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity.

CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors.Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to protect genome integrity by modulating PP4c activity in response to genotoxic stress.Recen

read more